Polynucleotide Bioregenerative Therapies

At Aesthetic Medicine Sydney, Rejuran is an advanced injectable treatment that supports skin quality, hydration, and elasticity through the introduction of polynucleotides (PN) derived from highly purified salmon DNA. These biocompatible polynucleotides act as a structural foundation, facilitating collagen formation and promoting cellular-level skin repair and regeneration. The result is potentially stronger, healthier, and more resilient skin that improves progressively over time.

Potential Benefits of Rejuran

Structural Support: Provides a biological framework that may support collagen synthesis, potentially enhancing skin elasticity, firmness, and overall resilience

Hydration & Barrier Function: May help restore skin integrity, improving moisture retention and reducing sensitivity and reactivity

Fine Lines & Wrinkles: May improve skin texture and firmness by reinforcing and strengthening underlying collagen networks

Tissue Repair: May support natural healing processes, potentially beneficial for addressing acne scarring, post-inflammatory marks, and damaged skin

Minimal Downtime: Natural, biologically-driven approach with gradual, sustained improvement and minimal disruption to daily activities

How Rejuran Works

Unlike traditional hyaluronic acid skin boosters that focus primarily on hydration, or biostimulators that work through different pathways, Rejuran at Aesthetic Medicine Sydney provides a unique structural matrix that may support comprehensive collagen regeneration and skin healing at a fundamental level.

The polynucleotides work by:

  • Creating a biological scaffold for collagen fiber formation, potentially improving skin strength, architecture, and elasticity over time

  • Enhancing tissue repair mechanisms and barrier function, potentially reducing inflammation and protecting against environmental damage

  • Improving hydration and overall skin quality, helping restore a smooth, even, and refined texture

Results typically develop gradually over 4–6 weeks as cellular regeneration begins, with continued enhancement over several months as collagen production and remodeling progress. At Aesthetic Medicine Sydney, a series of 3–4 treatment sessions, spaced 2–4 weeks apart, is commonly recommended to achieve optimal, long-lasting outcomes.

Who May Benefit from Rejuran

Rejuran at Aesthetic Medicine Sydney may be particularly suitable for individuals seeking to:

  • Strengthen collagen networks for improved skin elasticity and firmness

  • Address fine lines, wrinkles, crepiness, and early signs of ageing

  • Support repair of damaged, thin, fragile, or sensitive skin

  • Improve the appearance of acne scarring or post-inflammatory textural concerns

  • Enhance overall skin hydration, resilience, and barrier function

  • Achieve long-term skin quality improvement through biological regeneration

Our experienced practitioners at Aesthetic Medicine Sydney assess individual suitability through comprehensive consultation. We will thoroughly review your concerns, outline potential considerations and risks, and explain realistic outcomes based on your unique clinical evaluation and skin assessment.

FAQ

  • Rejuran works through a distinct regenerative mechanism focused on providing structural support for collagen synthesis and tissue repair. Unlike hyaluronic acid-based skin boosters that primarily enhance hydration, or calcium hydroxylapatite biostimulators that work through different stimulatory pathways, Rejuran's polynucleotides create a biological scaffold that supports comprehensive skin regeneration. Your practitioner will explain these important distinctions and help determine which treatment approach best addresses your specific skin concerns and goals.

  • Treatment protocols are individualised based on your skin condition, concerns, desired outcomes, and initial response to therapy. Most patients benefit from an initial series of 3–4 sessions to achieve optimal regenerative results, followed by periodic maintenance treatments. Your practitioner will recommend a tailored treatment plan during your consultation at Aesthetic Medicine Sydney.

  • Recovery experiences vary among individuals, though most patients experience minimal disruption to their daily routines. Some temporary effects such as mild swelling, redness, or small papules at injection sites may occur but typically resolve within days. Specific aftercare guidance and expectations will be provided during your consultation to ensure you feel fully prepared.

  • Results from Rejuran develop progressively as the polynucleotides support collagen regeneration and cellular repair. Initial improvements in hydration and skin texture may be noticed within weeks, with continued enhancement in firmness, elasticity, and overall skin quality emerging over the following months. Your practitioner will provide a realistic timeline during your consultation, helping you understand the gradual nature of this regenerative treatment.

  • As with any medical interventions, potential side effects may occur. These are typically mild and temporary, such as tenderness, swelling, redness, or small bumps at injection sites. At Aesthetic Medicine Sydney, we prioritise thorough patient education and will comprehensively discuss all relevant considerations, potential reactions, safety protocols, and aftercare requirements during your consultation to ensure you feel confident and well-informed.